Here are some key highlights of how the Spanish flu ultimately ended, and how it might correlate to the COVID-19 pandemic. History says the Spanish flu lasted from February 1918 until April 1920, but there wasn’t a definitive statement that the pandemic was over, according to Time. Of course, by then, the Spanish flu did unspeakable damage, infecting 500 million people and killing 50 million. With technology and research being nowhere close to what it is now, there was no waiting around for a vaccine to help quell the Spanish flu. That might have been the case with the Spanish flu, as people’s tolerance to the disease and willingness to social distance, wash hands and wear masks throughout increased.