Trevor Lawrence’s professional debut opened with a sack and a fumble, hardly ideal but not too concerning for the Jacksonville Jaguars.

The undefeated Titans are healing up from the NFL’s first COVID-19 outbreak. DeCastro will miss his third game of the season after sustaining an abdominal injury last week against Philadelphia. Johnson, Pittsburgh’s second-leading receiver, is out because of a back injury suffered on a punt return last week. Cincinnati also will be missing starting defensive tackle D.J. Eagles: RT Lane Johnson, WR DeSean Jackson, WR Alshon Jeffery, CB Avonte Maddox, S Marcus Epps, LB Duke Riley, QB Nate Sudfeld.

(AP Photo/David Richard)CLEVELAND – Bill Belichick was their coach and Nick Saban was on his staff the last time the Cleveland Browns were this good this early. On the Colts' next possession, Browns safety Sheldrick Redwine, who came in while Harrison was being evaluated for a concussion, picked off Rivers. The defense bowed up in the second half and played well enough to win. Mayfield showed patience on his 2-yard scoring pass to Hunt, which gave the Browns a 10-7 lead early in the second quarter. Rookie LB Jacob Phillips injured his knee in the second half.