Manuel Margot flared a run-scoring single to right field to complete a two-run ninth and the playoff-bound Tampa Bay Rays beat the Los Angeles Angels 5-4.

Luke Raley hit a tiebreaking homer in the seventh inning, and Tampa Bay’s remarkable bullpen retired everyone it faced in the Rays’ 4-3 victory over the Baltimore Orioles on Thursday night in the opener of a huge series at Camden Yards.

Colton Cowser hit a sacrifice fly in the 10th inning, and the AL East-leading Baltimore Orioles beat the Tampa Bay Rays 4-3 in the opener of a four-game series between the American League’s top teams.

San Diego star third baseman Manny Machado sprained his left ankle while taking a tumble running out a grounder and the Colorado Rockies completed a three-game sweep, beating the Padres 8-3.

Freddie Freeman reached base three times and scored a run in his Dodgers debut, helping Walker Buehler and Los Angeles beat the Colorado Rockies 5-3 in a season opener.

Shohei Ohtani continued his power display Wednesday, crushing a three-run home run, and Phil Gosselin had a go-ahead RBI single in the eighth inning for the Los Angeles Angels, who rallied for an 8-7 victory over the Colorado Rockies.

Josh Fuentes capped a big night with a two-out, walk-off single in the eighth inning after earlier hitting a two-run homer and the Colorado Rockies salvaged a doubleheader split by beating the virus-hampered San Diego Padres 3-2.

Vintage Javier Bez, in time to keep the Cubs' surge going. Bez took it from there, emerging from a slow start that included only a pair of singles in the first four games. Mills, who made four spot starts last season, held the Reds to two hits in six innings. Bez had a solo shot and a two-run homer as the Cubs pulled away, loudly cheering each hit and celebrating each run in the dugout. Reds: Sonny Gray (1-0) tries to extend his major league record streak of 34 consecutive starts without allowing more than six hits.