Carlos Alcaraz’s bid to win a third straight Madrid Open title has ended with a three-set loss to Andrey Rublev in the quarterfinals.

Novak Djokovic will begin his bid to win the U.S. Open for a men’s-record 21st major tennis championship and to complete a calendar-year Grand Slam by facing a player who comes through qualifying.

Rafael Nadal has improved his French Open career record to 101-2 as he pursues a 14th championship there and his record-breaking 21st Grand Slam title overall.

Japan's Naomi Osaka walks out onto court for her match against Britain's Katie Boulter during a tuneup event ahead of the Australian Open tennis championships in Melbourne, Australia, Wednesday, Feb. 3, 2021. The Australian Open is scheduled to begin Monday. Australian Open organizers didn’t immediately have details of how many players were ordered to isolate. Williams won her last major title at the 2017 Australian Open, when she was pregnant with her daughter, Olympia. On the bottom half of the draw, defending Australian Open champion Sofia Kenin rallied from a set and a break down to fend off Jessica Pegula 5-7, 7-5, 6-2.

Serbia's Novak Djokovic plays a shot against Colombia's Daniel Elahi Galan in the third round match of the French Open tennis tournament at the Roland Garros stadium in Paris, France, Saturday, Oct. 3, 2020. Is it the two-week gap from the end of the U.S. Open to the start of the French Open? The other fourth-round men’s matches Monday: Djokovic vs. No. The women’s matchups established Saturday: Australian Open champion Sofia Kenin against Fiona Ferro; two-time Wimbledon champion Petra Kvitova against Zhang Shuai; Paula Badosa against Laura Siegemund; amd No. The 22-year-old from Spain, ranked 87th, defeated 2017 French Open champion Jelena Ostapenko 6-4, 6-3.

NEW YORK The Latest on the U.S. Open tennis tournament (all times local):11:10 a.m. Play is underway in third-round matches on Day 5 at the U.S. Open. Past champions Naomi Osaka and Novak Djokovic are among those scheduled to play in Arthur Ashe Stadium later Friday. Osaka will face Marta Kostyuk to begin the day session in the tournaments main arena. The top-seeded Djokovic will bring a 28-match winning streak, including 25-0 this season, into his night match against Jan-Lennard Struff.

Naomi Osaka, of Japan, leaves the court after winning her match with Anett Kontaveit, of Estonia, during the quarterfinals at the Western & Southern Open tennis tournament Wednesday, Aug. 26, 2020, in New York. Soon after, the whole tournament was put on hold for a day. Osaka tweeted that as a Black woman, she feels compelled to pull out of the tournament to put a focus on police shooting Black people. "Watching the continued genocide of Black people at the hand of the police is honestly making me sick to my stomach. I have to be patient, to try to enjoy every single match I play here after six months without competing.

Novak Djokovic, of Serbia, returns a shot from Tennys Sandgren during the third round at the Western & Southern Open tennis tournament Tuesday, Aug. 25, 2020, in New York. (AP Photo/Frank Franklin II)NEW YORK Novak Djokovics neck felt much better, and his tennis looked much better, in a 6-2, 6-4 victory over unseeded American Tennys Sandgren at the Western & Southern Open on Tuesday that improved the No. The Western & Southern Open is usually held in Ohio but was moved to the U.S. Opens site in Flushing Meadows this year to make for a two-event, no-spectator bubble amid the pandemic. He has won five of the past seven Grand Slam tournaments, including at the Australian Open in February. Womens quarterfinal matchups set earlier in the day were two-time Grand Slam champion Naomi Osaka against Anett Kontaveit, former No.