Plenty of playoff contenders suddenly find themselves dealing with major injuries to notable players as the college football season reaches its halfway point.

Kevin Jennings passed for a career-high 281 yards, Isaiah Nwokobia intercepted an end-zone pass with 2:23 left to seal it, and SMU overcame blowing a double-digit lead to beat No. 22 Louisville 34-27.

Bryce Young passed for three touchdowns and rushed for a fourth, Will Anderson Jr. scored on an interception return and No. 2 Alabama rolled to a 63-7 victory over Louisiana-Monroe.

With Jameson Williams and John Metchie III sidelined by injuries, Bryce Young had his Heisman Trophy-winning season effectively ended by a last-minute pick six in the College Football Playoff championship game.

Georgia coach Kirby Smart sees challenges everywhere for his defense — even with Alabama missing one of its top receivers.