The Jacksonville Jaguars have ended their 20-game losing streak.

Sam Darnold threw for 305 yards and two touchdowns, and the Carolina defense turned in another strong performance in a 26-7 win over the New Orleans Saints.

San Francisco 49ers running back Jeff Wilson (30) celebrates his touchdown against the Arizona Cardinals with quarterback C.J. Beathard threw three touchdown passes, Jeff Wilson ran for 183 yards, and the San Francisco 49ers dealt a brutal blow to the Arizona Cardinals' playoff hopes by defeating them 20-12 on Saturday. If the Chicago Bears win their final two games, they will reach the playoffs because of a tiebreaker over the Cardinals. The 49ers (6-9) pulled ahead 14-6 in the third quarter on Beathard’s 9-yard touchdown pass to fullback Kyle Juszczyk. Cardinals: LB Haason Reddick (hamstring) left the game in the first quarter, but returned early in the second quarter.